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IL-28A Polyclonal Antibody, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

$250.00 - $2175.00

Specifications

Antigen IL-28A
Concentration 0.1-1.0 mg/mL
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
500P24750UG
Encompass_Preferred
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Invitrogen™
500P24750UG
50 μg
Each for $250.00
Only null left
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500P247100
Encompass_Preferred
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Invitrogen™
500P247100UG
100 μg
Each for $319.00
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500P2471MG
Encompass_Preferred
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Invitrogen™
500P2471MG
1 mg
Each for $2,175.00
Only null left
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Description

Description

AA Sequence of recombinant protein: PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IFN-lambda2. Anti-Human IFN-lambda2-specific antibody was purified by affinity chromatography employing an immobilized Human IFN-lambda2 matrix. Sandwich ELISA: To detect Human IFN-lambda2 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human IFN-lambda2 (500-P247Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human IFN-lambda2. Western Blot: To detect Human IFN-lambda2 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human IFN-lambda2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

IL-28A belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), and are also known as the type III Interferons.The IFN lambdas signal through a heterodimeric receptor of which one subunit, IL-10R2, is shared with other members of the superfamily. The second subunit, IFN lambda R1 or IL-28R alpha, is unique to the IFN lambdas. Signaling occurs through the Jak/STAT pathway in a similar manner as the type I IFN (IFN alpha/beta) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral activity through the induction of antiviral protein production in target cells and the upregulation of MHC class I expression. These proteins also exhibit antiproliferative and antitumor effects, making them a possible alternative to IFN alpha cancer therapies. Unlike the type I IFN, which are able to stimulate most cells, response to IFN lambda stimulation appears to be limited to dendritic and some tumor cells due to the limited expression of IFN lambda R1. Another notable difference is the ability of the IFN lambda stimulation to drive dendritic cells towards the production of CD4+CD25+FoxP3+ regulatory T cells, suggesting a possible immunoregulatory role
Specifications

Specifications

IL-28A
ELISA, Western Blot
Unconjugated
Rabbit
Human
Q8IZJ0
282616
E.coli-derived Recombinant Human IFN-lambda2.
Antigen affinity chromatography
IFNL2
0.1-1.0 mg/mL
Polyclonal
Lyophilized
RUO
PBS with no preservative
cytokine Zcyto20; EG330496; Ifnl2; IFN-lambda2; IFN-lambda-2; Il28a; IL-28A; ILN; interferon lambda 2; interferon lambda-2; interferon, lambda 2; interferon-lambda 2; interferon-lambda2; Interleukin; interleukin 28A; interleukin 28A (interferon, lambda 2); interleukin-28A; ZCYTO20
IFNL2
Primary
-20°C
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