Invitrogen™ IL-29 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587056

Catalog No. PIPA587056

Description

Purity is > 95% by SDS-PAGE.

IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.

Specifications

• Antigen: IL-29
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IFNL1
• Gene Alias: cytokine Zcyto21; Cytokine Zcyto22; FNL1; IFN lambda1; IFNL1; IFNL3; IFN-lambda-1; IFN-lambda-3; IFN-lambda-4; IL28B; IL-28B; IL28C; IL-28C; IL29; IL-29; ILN; interferon lambda 1; interferon lambda 3; Interferon lambda1; interferon lambda-1; Interferon lambda-3; interferon, lambda 1; interferon, lambda 3; interferon, lambda 4; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); interleukin-28B; Interleukin-28C; interleukin-29; ZCYTO21; ZCYTO22
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100911249, 282618
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IU54
• Gene Symbols: IFNL1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human IFNL1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG