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Invitrogen™ IL-31 Monoclonal Antibody (B7-B0)
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Catalog No. PIMA532892
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100 μL
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PIMA532892 100 μL
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Catalog No. PIMA532892 Supplier Invitrogen™ Supplier No. MA532892
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Description

Mouse Monoclonal Antibody

IL-31 Monoclonal Antibody for ELISA, Western Blot

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
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Specifications

Antigen IL-31
Applications ELISA, Western Blot
Classification Monoclonal
Clone B7-B0
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% Glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene Il31
Gene Accession No. Q6EBC2
Gene Alias 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31
Gene Symbols Il31
Host Species Mouse
Immunogen Recombinant protein within Human Interleukin 31 aa 1-164.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386653
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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