Invitrogen™ IL-31 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547405

Catalog No. PIPA547405

Description

In sandwich ELISAs, less than 1% cross-reactivity with recombinant mouse IL-31 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Specifications

• Antigen: IL-31
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Il31
• Gene Alias: 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 386653
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: ELISA, Neutralization, Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q6EBC2
• Gene Symbols: Il31
• Immunogen: E. coli-derived recombinant human IL-31 Ser24-Thr164.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG