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PeproTech IL-31 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Catalog No. 502718571
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Catalog No. Quantity
50-271-8571 500 μg
500P249BT25 25 μg
500P249BT50 50 μg
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Catalog No. 50-271-8571 Supplier PeproTech Supplier No. 500P249BT500UG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-31. Anti-Human IL-31-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect hIL-31 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human IL-31 (500-P249) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant hIL-31. Western Blot: To detect hIL-31 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hIL-31 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P249BT-1MG will be provided as 2 x 500 μg

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-31
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Biotin
Formulation PBS with no preservative
Gene Il31
Gene Accession No. Q6EBC2
Gene Alias 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31
Gene Symbols Il31
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human IL-31.
Purification Method Antigen affinity chromatography
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386653
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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