IL-8 (CXCL8) Monoclonal Antibody (KT215), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA549463

Catalog No. PIMA549463

Description

This product was used in both Indirect and Sandwich ELISA. This product does not cross-react with human IL1B, IL2, IL4, IL5, IL6, IL7, IL9, IL10, IL11, IL12, IL13, IL17A, CSF2, IFNA, IFNG, CCL2, KITLG and TNF. This product can be paired with MA5-49465.

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

Specifications

• Antigen: IL-8 (CXCL8)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P10145
• Gene Symbols: CXCL8
• Immunogen: Recombinant human CXCL8 (P00726PA)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: KT215
• Conjugate: Unconjugated
• Gene: CXCL8
• Gene Alias: (Ala-IL-8)77, (Ser-IL-8)72, Alveolar macrophage chemotactic factor I, alveolar macrophage-derived chemotactic factor-I, AMCF-I, ANX7, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, C-X-C motif chemokine 8, C-X-C motif chemokine ligand 8, CXCL8, cytokine 8, emoctakin, GCP/IL-8 protein I, GCP/IL-8 protein II, GCP/IL-8 protein III, GCP/IL-8 protein IV, GCP/IL-8 protein V, GCP/IL-8 protein VI, GCP1, GCP-1, Granulocyte chemotactic protein 1, IL8, IL-8, IL-8(1-77), IL-8(5-77), IL-8(6-77), IL-8(7-77), IL-8(8-77), IL-8(9-77), IL8/NAP1 form I, IL8/NAP1 form II, IL8/NAP1 form III, IL8/NAP1 form IV, IL8/NAP1 form V, IL8/NAP1 form VI, ILN, Interleukin, interleukin 8, Interleukin8, interleukin-8, interleuklin-8 precursor, LECT, LUCT, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, Lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF, MDNCF-a, MDNCF-b, MDNCF-c, MONAP, Monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, NAF, NAP1, NAP-1, neutrophil activating peptide 1, neutrophil and T-lymphocyte chemotactic and activating factor, Neutrophil attractant/activation protein 1, neutrophil attractant/activation protein-1, Neutrophil-activating factor, neutrophil-activating peptide 1, Neutrophil-activating protein 1, Permeability factor 1, PF1, Protein 3-10C, RP11-537A6.8, RPF1, small inducible cytokine subfamily B, member 8, SNX, SYNEXIN, T-cell chemotactic factor, tumor necrosis factor-induced gene 1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3576
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Isotype: IgG1 κ