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Invitrogen™ IL10RA Chimeric Recombinant Rabbit Monoclonal Antibody (1B1.3a)
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Catalog No. PIMA548250
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200 μg
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PIMA548250 200 μg
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Catalog No. PIMA548250 Supplier Invitrogen™ Supplier No. MA548250
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody recognises mouse IL-10R which is a cell surface glycoprotein and a receprot for anti-inflammatory IL-10. The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse IL-10R.

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL10RA Chimeric
Applications Flow Cytometry, Inhibition Assays, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 1B1.3a
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Il10ra
Gene Accession No. Q61727
Gene Alias AW553859; CD210; CD210a; CDw210; CDW210A; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; HIL-10R; I10R; I10R1; il-10 receptor; il-10 receptor antagonist; IL-10 receptor subunit alpha; IL10R; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10R2; Il10ra; IL-10RA; interleukin 10 receptor subunit alpha; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha; mIL-10R
Gene Symbols Il10ra
Host Species Rabbit
Immunogen This antibody was raised by immunising rats with the purified recombinant extracellular region of mouse Interleukin 10 Receptor.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16154
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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