IL12A Monoclonal Antibody (OTI1G5), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1920	100 μL

Catalog No. 50-168-1920 Supplier OriGene Supplier No. TA808129

Description

Mouse Monoclonal Antibody

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

Specifications

• Antigen: IL12A
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1G5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: IL12A
• Gene Accession No.: P29459
• Gene Alias: CLMF, IL-12A, NFSK, NKSF1, P35
• Gene Symbols: IL12A
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 57-253 of human IL12A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3592
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1