IL12A Mouse anti-Human, Clone: OTI2A8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF808081

Catalog No. 50-166-8626

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

Specifications

• Antigen: IL12A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IL12A
• Gene Alias: CLMF, IL-12A, NFSK, NKSF1, P35
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3592
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2A8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P29459
• Gene Symbols: IL12A
• Immunogen: Human recombit protein fragment corresponding to amino acids 57-253 of human IL12A produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1