IL12RB1 Mouse anti-Human, Clone: OTI1A6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF808195

Catalog No. 50-166-8684

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Specifications

• Antigen: IL12RB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IL12RB1
• Gene Alias: CD212, IL-12R-BETA1, IL12RB, IMD30
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3594
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1A6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P42701
• Gene Symbols: IL12RB1
• Immunogen: Human recombit protein fragment corresponding to amino acids 33-283 of human IL12RB1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1