Invitrogen™ IL17C Polyclonal Antibody

Catalog No.	Quantity
PIPA547296	100 μg

Catalog No. PIPA547296 Supplier Invitrogen™ Supplier No. PA547296

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 35% cross-reactivity with recombinant human IL-17C is observed, and less than 5% cross-reactivity with recombinant mouse (rm) IL-17, rmIL-17B, rmIL-17D, rmIL-17E, and rmIL-17F is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Specifications

• Antigen: IL17C
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: IL17C
• Gene Accession No.: Q8K4C5
• Gene Alias: CX2; cytokine CX2; Il17c; IL-17C; IL-21; Interleukin; interleukin 17C; interleukin-17C; UNQ561/PRO1122
• Gene Symbols: IL17C
• Host Species: Goat
• Immunogen: E. coli-derived recombinant mouse IL-17C His15-Gln194.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 234836
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG