Invitrogen™ IL17C Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547296

Catalog No. PIPA547296

Description

In direct ELISAs and Western blots, approximately 35% cross-reactivity with recombinant human IL-17C is observed, and less than 5% cross-reactivity with recombinant mouse (rm) IL-17, rmIL-17B, rmIL-17D, rmIL-17E, and rmIL-17F is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Specifications

• Antigen: IL17C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL17C
• Gene Alias: CX2; cytokine CX2; Il17c; IL-17C; IL-21; Interleukin; interleukin 17C; interleukin-17C; UNQ561/PRO1122
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234836
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8K4C5
• Gene Symbols: IL17C
• Immunogen: E. coli-derived recombinant mouse IL-17C His15-Gln194.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG