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Invitrogen™ IL17C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103436

Catalog No. PIPA5103436


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Description

Description

Antibody detects endogenous levels of total IL17C.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IL17C
Polyclonal
Unconjugated
IL17C
CX2; cytokine CX2; Il17c; IL-17C; IL-21; Interleukin; interleukin 17C; interleukin-17C; UNQ561/PRO1122
Rabbit
Affinity chromatography
RUO
234836, 27189
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q8K4C5, Q9P0M4
IL17C
A synthesized peptide derived from human IL17C(Accession Q9P0M4), corresponding to amino acid residues R141-C191.
100 μL
Primary
Human, Mouse
Antibody
IgG
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