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Invitrogen™ IL17RA Monoclonal Antibody (133617)
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Catalog No. PIMA523864
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100 μg
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Catalog No. Quantity
PIMA523864 100 μg
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Catalog No. PIMA523864 Supplier Invitrogen™ Supplier No. MA523864
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Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant mouse (rm) IL-17 R, rmIL-17B R, or recombinant human IL-17B R is observed. In Western blots, no cross-reactivity with rmIL-17 R is observed Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL17RA
Applications Flow Cytometry, Neutralization, Western Blot
Classification Monoclonal
Clone 133617
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Il17ra
Gene Accession No. Q96F46
Gene Alias AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217
Gene Symbols Il17ra
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human IL-17RA/IL-17R Leu33-Trp320.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23765
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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