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Invitrogen™ IL17RB Polyclonal Antibody
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Catalog No. PIPA587674
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100 μL
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PIPA587674 100 μL
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Catalog No. PIPA587674 Supplier Invitrogen™ Supplier No. PA587674
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP; Positive Samples: HepG2, 293T, SW620, A-549, B-cell, Mouse liver, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein.

Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL17RB
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene IL17RB
Gene Accession No. Q9JIP3, Q9NRM6
Gene Alias CRL4; cytokine receptor CRL4; cytokine receptor-like 4; ecotropic viral integration site 27; EVI27; IL-17 receptor B; IL-17 receptor homolog 1; IL-17B; IL-17B receptor; IL17BR; IL-17ER; Il17rb; IL-17RB; IL17RH1; IL-17Rh1; IL-20; interleukin 17 receptor B; interleukin 17 receptor homolog 1; interleukin 17B receptor; interleukin-17 receptor B; Interleukin-17B receptor; MGC138900; MGC138901; MGC5245; UNQ2501/PRO19612; ZCYTO7
Gene Symbols IL17RB
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_0611952).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 306247, 50905, 55540
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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