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Invitrogen™ IL17RC Polyclonal Antibody
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Catalog No. PIPA547285
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100 μg
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PIPA547285 100 μg
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Catalog No. PIPA547285 Supplier Invitrogen™ Supplier No. PA547285
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse IL-17 RC and 5% cross-reactivity with recombinant human (rh) IL-17 R, rhIL-17 RD, and rhIL-17B R is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL17RC
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene IL17RC
Gene Accession No. Q8NAC3
Gene Alias 1110025H02Rik; CANDF9; Gm19850; IL-17 receptor C; IL17F receptor; IL17RC; IL-17RC; IL17-RC; IL17Rhom; Il17rl; IL-17RL; IL17-RL; interleukin 17 receptor C; interleukin-17 receptor C; Interleukin-17 receptor homolog; interleukin-17 receptor-like protein; UNQ6118/PRO20040/PRO38901; ZcytoR14
Gene Symbols IL17RC
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human IL-17 RC Leu21-Ala454.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84818
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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