Invitrogen™ IL17RC Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547285

Catalog No. PIPA547285

Description

In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse IL-17 RC and 5% cross-reactivity with recombinant human (rh) IL-17 R, rhIL-17 RD, and rhIL-17B R is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

Specifications

• Antigen: IL17RC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL17RC
• Gene Alias: 1110025H02Rik; CANDF9; Gm19850; IL-17 receptor C; IL17F receptor; IL17RC; IL-17RC; IL17-RC; IL17Rhom; Il17rl; IL-17RL; IL17-RL; interleukin 17 receptor C; interleukin-17 receptor C; Interleukin-17 receptor homolog; interleukin-17 receptor-like protein; UNQ6118/PRO20040/PRO38901; ZcytoR14
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84818
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8NAC3
• Gene Symbols: IL17RC
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human IL-17 RC Leu21-Ala454.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG