Invitrogen™ IL18BP Polyclonal Antibody

Catalog No.	Quantity
PIPA559412	100 μL

Catalog No. PIPA559412 Supplier Invitrogen™ Supplier No. PA559412

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RLWEGSTSRE RGSTGTQLCK ALVLEQLTPA LHSTNFSCVL VDPEQVVQRH VVLAQLWAGL RATLPPTQEA LPSSHSSPQQ QG Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 56%.

Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity. As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to a variety of diseases, including eczema, asthma, and the autoimmune condition, Crohn's disease. The upregulation of IL-18BP by keratinocytes expressing the human papillomavirus (HPV) E7 oncoprotein has been shown to decrease IL-18-induced IFN-gamma production and IL-18-mediated T cell activation. Elevated levels of IL-18 and IL-18BP, as well as proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta and IL-8, have been linked to chronic inflammation and observed in macrophages (including Kupffer cells) isolated from lesions and intestinal tissues of Crohn's disease patients. As a member of the immunoglobulin-like class of receptors, IL-18BP contains a single immunoglobulin (Ig) domain; although two (b and d) of the four identified human isoforms (a-d) contain incomplete domains that greatly reduce their binding affinity.

Specifications

• Antigen: IL18BP
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: IL18BP
• Gene Accession No.: O95998
• Gene Alias: Igifbp; Il18bp; IL-18BP; IL18BPa; interferon gamma inducing factor binding protein; interferon gamma-inducing factor-binding protein; interleukin 18 binding protein; interleukin-18 binding protein; interleukin-18-binding protein; MC51L-53L-54L homolog gene product; MC54L; Tadekinig-alfa
• Gene Symbols: IL18BP
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human IL18BP. Recombinant protein control fragment (Product #RP-102904).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10068
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG