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Invitrogen™ IL1F6 Monoclonal Antibody (OTI3A2)
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Catalog No. PIMA525185
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100 μL
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PIMA525185 100 μL
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Catalog No. PIMA525185 Supplier Invitrogen™ Supplier No. MA525185
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Description

Mouse Monoclonal Antibody

IL1F6 Monoclonal Antibody for Western Blot, ICC/IF, Flow

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL1F6
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3A2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene IL36A
Gene Accession No. Q9UHA7
Gene Alias FIL1; FIL1 epsilon; FIL1(EPSILON); Fil1e; Fil1epsilon; IL-1 epsilon; IL1(EPSILON); Il1e; Il1f6; IL-1F6; IL-1F6 (FIL-1-epsilon); Il1f9; Il1h1; IL-1H1; IL1RP2; Il36a; Interleukin; interleukin 1; interleukin 1 family, member 6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin 1, epsilon; interleukin 36, alpha; interleukin-1 epsilon; Interleukin-1 family member 6; interleukin-1 homolog 1; Interleukin-36; Interleukin-36 alpha
Gene Symbols IL36A
Host Species Mouse
Immunogen Full length human recombinant protein of IL1F6 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27179
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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