Invitrogen™ IL1F6 Polyclonal Antibody

Catalog No.	Quantity
PIPA5100832	100 μL

Catalog No. PIPA5100832

Supplier: Invitrogen™ PA5100832

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IL1F6.

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.

Specifications

• Antigen: IL1F6
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: IL36A
• Gene Accession No.: Q9JLA2, Q9UHA7
• Gene Alias: FIL1; FIL1 epsilon; FIL1(EPSILON); Fil1e; Fil1epsilon; IL-1 epsilon; IL1(EPSILON); Il1e; Il1f6; IL-1F6; IL-1F6 (FIL-1-epsilon); Il1f9; Il1h1; IL-1H1; IL1RP2; Il36a; Interleukin; interleukin 1; interleukin 1 family, member 6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin 1, epsilon; interleukin 36, alpha; interleukin-1 epsilon; Interleukin-1 family member 6; interleukin-1 homolog 1; Interleukin-36; Interleukin-36 alpha
• Gene Symbols: Il1f6, IL36A
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human IL36A(Accession Q9UHA7), corresponding to amino acid residues E89-I139.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27179, 54448
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG