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IL1F9 Mouse anti-Human, Clone: OTI6E4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF505995

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.Specifications
IL1F9 | |
Monoclonal | |
Unconjugated | |
IL36G | |
IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
56300 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunohistochemistry (Paraffin), Western Blot | |
OTI6E4 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9NZH8 | |
IL36G | |
Full length human recombit protein of human IL1F9 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
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