Invitrogen™ IL1RA Monoclonal Antibody (35730 (49/20))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA182844

Catalog No. PIMA182844

Description

This antibody does not react with rmIL-1 RI or rhIL-1 RII in either Western blot or ELISA applications. Mouse anti human CD121a, clone 35730, recognizes interleukin-1 receptor type 1 (IL1R1). IL1RA/CD121a is widely expressed in a number of cell types including T cells and fibroblasts (Sims et al.)and is involved in the activation of NF-kappa-B (Slack et al.).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Specifications

• Antigen: IL1RA
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with <5% trehalose and 0.09% sodium azide; pH 7.2
• Gene Accession No.: P18510
• Gene Symbols: IL1RN
• Immunogen: Recombinant peptide corresponding to the extracellular domain of human CD121a expressed in insect cell line Sf21.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 35730 (49/20)
• Conjugate: Unconjugated
• Gene: IL1RN
• Gene Alias: Anakinra; CD121A; cytokine; D2S1473; DIRA; F630041P17Rik; ICIL-1RA; IL 1 receptor antagonist; IL1 inhibitor; il1 receptor; il-1 receptor; IL1 receptor antagonist; IL1F3; IL1R; il-1r; IL1RA; IL-1RA; IL1-RA; IL-1ra3; IL-1R-alpha; IL1RN; IL-1RN; IL1RN (IL1F3); interleukin 1 receptor antagonist; interleukin-1 receptor; interleukin-1 receptor antagonist; interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist secretory form; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); IRAP; IRAP1; MGC10430; MVCD4; P80; type II interleukin-1 receptor antagonist
• Host Species: Mouse
• Purification Method: affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3557
• Content And Storage: -20°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov