IL21R Mouse anti-Human, Clone: 1D1C2, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6751	Proteintech Group Inc 663191IG150UL	150 μL

Description

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

Specifications

• Antigen: IL21R
• Concentration: 1.5 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CD360, IL 21 receptor, IL 21R, IL21R, interleukin 21 receptor, NILR, Novel interleukin receptor
• Gene Symbols: IL21R
• Isotype: IgG2b
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 1D1C2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: Q9HBE5
• Gene ID (Entrez): 50615
• Immunogen: IL21R Fusion Protein Ag21295
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: IL21R