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Invitrogen™ IL21R Polyclonal Antibody
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Catalog No. PIPA596690
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100 μL
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PIPA596690 100 μL
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Catalog No. PIPA596690 Supplier Invitrogen™ Supplier No. PA596690
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GVSMPRGWAA PLLLLLLQGG WGCPDLVCYT DYLQTVICIL EMWNLHPSTL TLTWQDQYEE LKDEATSCSL HRSAHNATHA TYTCHMDVFH FMADDIFSVN ITDQSGNYSQ ECGSFLLAES IKPAPPFNVT VTFSGQYNIS WRSDYEDPAF YMLKGKLQYE LQYRNRGDPW AVSPRRKLIS VDSRSVSLLP LEFRKDSSYE LQVRAGPMPG SSYQGTWSEW S; Positive Samples: U-87MG, Mouse spleen, Mouse thymus; Cellular Location: Membrane, Single-pass type I membrane protein.

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL21R
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.21 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Il21r
Gene Accession No. Q9HBE5, Q9JHX3
Gene Alias CD360; IL-21 receptor; Il21r; IL-21R; interleukin 21 receptor; interleukin-21 receptor; LR-beta; lymphocyte receptor beta; MGC10967; NILR; novel cytokine receptor 8; Novel interleukin receptor; NR8; UNQ3121/PRO10273
Gene Symbols Il21r
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human IL21R (NP_8515654).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50615, 60504
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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