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Invitrogen™ IL23R Monoclonal Antibody (258010)
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Catalog No. PIMA523906
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100 μg
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Catalog No. Quantity
PIMA523906 100 μg
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Catalog No. PIMA523906 Supplier Invitrogen™ Supplier No. MA523906
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Description

Rat Monoclonal Antibody

In Western blots, this antibody does not cross-react with recombinant human IL-23 R. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL23R
Applications Neutralization, Western Blot
Classification Monoclonal
Clone 258010
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Il23r
Gene Accession No. Q8K4B4
Gene Alias IBD17; IL 23R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin 23 receptor-like; interleukin-23 receptor
Gene Symbols Il23r
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse IL-23 R Gly24-Asp372.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 209590
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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