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IL31 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 228591AP

Catalog No. 50-173-3957


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Description

Description

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Specifications

Specifications

IL31
0.26 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6EAL8, Q6EBC2
IL 31, IL31, interleukin 31
Rabbit
IgG
150 μL
-20°C
Primary
386653, 76399
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
IL31
Liquid
IL31
IL31 Fusion Protein Ag18848
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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