Invitrogen™ IL31RA Polyclonal Antibody

Catalog No.	Quantity
PIPA5111631	100 μL

Catalog No. PIPA5111631 Supplier Invitrogen™ Supplier No. PA5111631

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ILKPCSTPSD KLVIDKLVVN FGNVLQEIFT DEARTGQENN LGGEKNGYVT CPFRPDCPLG KSFEELPVSP EIPPRKSQYL R Highest antigen sequence indentity to the following orthologs: Rat - 51%, Mouse - 52%.

IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

Specifications

• Antigen: IL31RA
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.10 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: IL31RA
• Gene Accession No.: Q8NI17
• Gene Alias: class I cytokine receptor; CRL; CRL 3; CRL3; CRL3Glmr; cytokine receptor NR10; cytokine receptor-like 3; GLM R; Glmr; GLM-R; GLM-RMGC125346; GP130 like receptor; gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLMR; hGLM-R; IL 31RA; IL-31 receptor subunit alpha; IL31R subunit alpha; IL-31R subunit alpha; Il31ra; IL-31RA; IL-31RAGPLCRL; IL-31R-alpha; interleukin 31 receptor A; interleukin 31RA; interleukin-31 receptor subunit alpha; MGC125346; mGLM-R; novel cytokine receptor 10; NR10; PLCA 2; PLCA2; PRO21384; soluble type I cytokine receptor CRL3; UNQ6368/PRO21073/PRO21384; ZcytoR17
• Gene Symbols: IL31RA
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human IL31RA. Recombinant protein control fragment (Product #RP-108537).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 133396
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG