Invitrogen™ IL36B Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547294

Catalog No. PIPA547294

Description

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1F8 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IL-1 alpha, rmIL-1 beta, rmIL-1ra, rmIL-18, rhIL-1F5, rmIL-1F6, rhIL-1F7, rhIL-1F9 and rhIL-1F10 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

Specifications

• Antigen: IL36B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Il1f8
• Gene Alias: 2310043N20Rik; family of interleukin 1-eta; FIL1; FIL1 eta; FIL1-(ETA); Fil1e; FIL1H; FILI-(ETA); IL-1 eta; IL1-ETA; IL1F8; IL-1F8; IL1F8 (Canonical product IL-1F8a); IL-1F8 (FIL1-eta); IL1H2; IL-1H2; Il36b; Interleukin; interleukin 1 family, member 8; interleukin 1 family, member 8 (eta); interleukin 1, eta; interleukin 36, beta; interleukin-1 eta; Interleukin-1 family member 8; interleukin-1 homolog 2; Interleukin-1 Superfamily e; interleukin-36 beta
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 69677
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Neutralization, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9D6Z6
• Gene Symbols: Il1f8
• Immunogen: E. coli-derived recombinant mouse IL-36 beta/IL-1F8 Met1-Lys183.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG