Invitrogen™ IL5RA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119930

Catalog No. PIPA5119930

Description

Positive Control: Hela cell lysate, PANC-1 cell lysate, Hela, human stomach carcinoma tissue, human thyroid carcinoma tissue. Subcellular Location: Membrane.

Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.

Specifications

• Antigen: IL5RA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL5RA
• Gene Alias: CD125; CD125 antigen; CDw125; HSIL5R3; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; Il5r; IL-5R subunit alpha; Il5ra; IL-5RA; IL-5R-alpha; interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; interleukin-5 receptor subunit alpha
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3568
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q01344
• Gene Symbols: IL5RA
• Immunogen: Synthetic peptide within human IL-5RA aa 31-80/420.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG