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Invitrogen™ ILP-2 Polyclonal Antibody
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Catalog No. PA14276
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100 μg
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PA14276 100 μg
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Catalog No. PA14276 Supplier Invitrogen™ Supplier No. PA14276
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Description

Rabbit Polyclonal Antibody

PA1-4276 detects the ILP-2 protein in human samples. PA1-4276 has been successfully used in Western blot procedures. PA1-4276 immunogen corresponds to amino acid residues 71-84 of the human ILP-2 protein.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
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Specifications

Antigen ILP-2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BIRC8
Gene Accession No. Q96P09
Gene Alias baculoviral IAP repeat containing 8; baculoviral IAP repeat-containing 8; baculoviral IAP repeat-containing protein 8; BIRC8; hILP2; IAP-like protein 2; ILP2; ILP-2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
Gene Symbols BIRC8
Host Species Rabbit
Immunogen Synthetic peptide: E(71) E K G H E Y I N N I H L T(84).
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112401
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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