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ILP2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987561
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50-198-7561 100 μL
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Catalog No. 50-198-7561 Supplier Bioss Supplier No. BS6870R
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Description

Rabbit Polyclonal Antibody

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Specifications

Antigen ILP2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene BIRC8
Gene Accession No. Q96P09
Gene Alias baculoviral IAP repeat containing 8; baculoviral IAP repeat-containing 8; baculoviral IAP repeat-containing protein 8; BIRC8; hILP2; IAP-like protein 2; ILP2; ILP-2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
Gene Symbols BIRC8
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ILP2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112401
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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