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Invitrogen™ Imalumab Recombinant Human Monoclonal Antibody
Human Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA542037
This item is not returnable.
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Description
Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Imalumab is a biosimilar that targets MIF. MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity.
Specifications
Imalumab | |
Recombinant Monoclonal | |
Unconjugated | |
BAX069; BAX69 | |
Human MIF. | |
100 μg | |
Primary | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid | |
Chemical |
ELISA, SDS-Page | |
3.94 mg/mL | |
PBS with no preservative; pH 7.4 | |
Human | |
Protein A | |
RUO | |
Human | |
Antibody | |
IgG1 κ |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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