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  8. IMD 0354, Tocris Bioscience™

IMD 0354, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
978-62-1
C15H8ClF6NO2
383.67
MFCD00218820
CHILCFMQWMQVAL-UHFFFAOYSA-N
ikk-2 inhibitor v, n-3,5-bis trifluoromethyl phenyl-5-chloro-2-hydroxybenzamide, n-3,5-bis-trifluoromethylphenyl-5-chloro-2-hydroxybenzamide, benzamide, n-3,5-bis trifluoromethyl phenyl-5-chloro-2-hydroxy, kinome_1864, d0z5dm, 3',5'-salicyloxylidide, 5-chloro-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro, imd hplc , solid
5081913
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
This item is not returnable. View return policy
978-62-1
C15H8ClF6NO2
383.67
MFCD00218820
CHILCFMQWMQVAL-UHFFFAOYSA-N
ikk-2 inhibitor v, n-3,5-bis trifluoromethyl phenyl-5-chloro-2-hydroxybenzamide, n-3,5-bis-trifluoromethylphenyl-5-chloro-2-hydroxybenzamide, benzamide, n-3,5-bis trifluoromethyl phenyl-5-chloro-2-hydroxy, kinome_1864, d0z5dm, 3',5'-salicyloxylidide, 5-chloro-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro, imd hplc , solid
5081913
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

Description

Inhibitor of IKKβ

Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Also antagonist at P2X1, P2X4 and P2X7 receptors (IC50 values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collegen in vitro.
Quantity 10 mg
Formula Weight 383.67
Percent Purity >99%
Chemical Name or Material IMD 0354

Safety and Handling

Recommended Storage : Store at +4°C