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Tocris Bioscience™ Imipramine hydrochloride
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Catalog No. 784150
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (Ki values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.

Specifications

Chemical Name or Material 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
CAS 113-52-0
Quantity 50 mg
Target Autophagy-related Compounds
Molecular Formula C19H24N2.HCl
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