Thermo Scientific™ ImmunoCAP™ Epidermal and Animal Protein Allergens

Catalog No.	Quantity	Code	Common Name	Regulatory Status
14-411-001P	16 Tests	e5	Dog dander	FDA Cleared
14-410-901P	16 Tests	e1	Cat dander	FDA Cleared
14-412-201P	16 Tests	e3	Horse dander	FDA Cleared
14-416-601P	16 Tests	e4	Cow dander	FDA Cleared
14-416-701P	16 Tests	e6	Guinea pig epithelium	FDA Cleared
14-416-901P	16 Tests	e70	Goose feathers	FDA Cleared
14-417-001P	10 Tests	e85	Chicken feathers	FDA Cleared
14-417-101P	10 Tests	e86	Duck feathers	FDA Cleared
14-430-401P	10 Tests	e78	Budgerigar feathers	FDA Cleared
14-430-801P	10 Tests	e82	Rabbit epithelium	FDA Cleared
14-430-301P	10 Tests	e77	Budgerigar droppings	FDA Cleared
14-430-701P	10 Tests	e81	Sheep epithelium	FDA Cleared
14-430-901P	10 Tests	e83	Swine epithelium	FDA Cleared
14-430-601P	10 Tests	e80	Goat epithelium	FDA Cleared
14-431-001P	10 Tests	e84	Hamster epithelium	FDA Cleared
14-432-601P	10 Tests	e87	Rat epithelium, serum proteins and urine proteins	FDA Cleared
14-432-701P	10 Tests	e88	Mouse epithelium, serum proteins and urine proteins	FDA Cleared
14-435-601P	10 Tests	e89	Turkey feathers	FDA Cleared
14-439-401P	10 Tests	e71	Mouse epithelium	FDA Cleared
14-439-501P	10 Tests	e72	Mouse urine proteins	FDA Cleared
14-439-701P	10 Tests	e74	Rat urine proteins	FDA Cleared
14-439-601P	10 Tests	e73	Rat epithelium	FDA Cleared
14-439-901P	10 Tests	e76	Mouse serum proteins	FDA Cleared
14-439-801P	10 Tests	e75	Rat serum proteins	FDA Cleared
14-482-401P	10 Tests	e201	Canary bird feathers	FDA Cleared
14-501-310P	10 Tests	Re214	Finch feathers	ASR
14-501-510P	10 Tests	Re209	Gerbil epithelium	ASR
14-503-410P	10 Tests	Re211	Rabbit, urine proteins	ASR
14-503-210P	10 Tests	Re215	Pigeon feathers	ASR
14-503-310P	10 Tests	Re206	Rabbit, serum proteins	ASR
14-515-710P	10 Tests	Re217	Ferret epithelium	ASR
14-523-010P	10 Tests	Re219	Chicken, serum proteins	ASR
14-522-910P	10 Tests	Re218	Chicken droppings	ASR
14-416-801P	16 Tests	e7	Pigeon droppings	FDA Cleared

Catalog No. 14-411-001P Supplier Thermo Scientific™ Supplier No. 14411001

Description

Measure specific IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Quantify specific IgE antibodies with ImmunoCAP™ Epidermal and Animal Protein Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Regulatory Status: FDA Cleared
• Code Type: Animal Protein
• Common Name: Dog dander
• Quantity: 16 Tests
• Code: e5