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Invitrogen™ IGF2BP3 Recombinant Rabbit Monoclonal Antibody (8K4H5)
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Catalog No. PIMA542816
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100 μL
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PIMA542816 100 μL
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Catalog No. PIMA542816 Supplier Invitrogen™ Supplier No. MA542816
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: 293T, HepG2, A-549. Immunogen sequence: NKLYIGNLSE NAAPSDLESI FKDAKIPVSG PFLVKTGYAF VDCPDESWAL KAIEALSGKI ELHGKPIEVE HSVPKRQRIR KLQIRNIPPH LQWEVLDSLL VQYGVVESCE QVNTDSETAV VNVTYSSKDQ ARQALDKLNG FQLENFTLKV AYIPDEMAAQ QNPLQQPRGR RGLGQRGSSR QGSPGSVSKQ KPC.

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IGF2BP3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 8K4H5
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene IGF2BP3
Gene Accession No. O00425
Gene Alias 2610101N11Rik; AA522010; Ab2-255; AL022933; AU045931; cancer/testis antigen 98; CT98; hKOC; IGF2 mRNA-binding protein 3; IGF2BP3; IGF-II mRNA-binding protein 3; IMP3; IMP-3; insulin like growth factor 2 mRNA binding protein 3; insulin-l; insulin-like growth factor 2 mRNA binding protein 3; insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC; KOC1; Koc13; mimp3; mIMP-3; Neilsen; RGD1306512; VICKZ family member 3; Vickz3
Gene Symbols IGF2BP3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 2-194 of human IMP3 (O00425).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10643
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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