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Invitrogen™ IMPA1 Monoclonal Antibody (1E6-F11)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA519204
Description
Peptide Sequence: MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED.
IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.
Specifications
IMPA1 | |
Monoclonal | |
0.2-1.0 mg/mL | |
PBS with no preservative; pH 7.4 | |
P29218 | |
Impa1 | |
IMPA1 (AAH08381, 1 a.a. ~ 277 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
50 μg | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
ELISA, Western Blot | |
1E6-F11 | |
Unconjugated | |
Impa1 | |
2610002K09Rik; 2900059K10Rik; AI325909; D-galactose 1-phosphate phosphatase; IMP; IMP 1; IMPA; IMPA1; Impa1-L; IMPase 1; inositol (myo)-1(or 4)-monophosphatase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1; testicular tissue protein Li 94 | |
Mouse | |
Affinity Chromatography | |
RUO | |
3612 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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