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Invitrogen™ IMPA1 Polyclonal Antibody
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Catalog No. PIPA583373
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100 μL
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PIPA583373 100 μL
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Catalog No. PIPA583373 Supplier Invitrogen™ Supplier No. PA583373
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CIPVHGIRSV GTAAVNMCLV ATGGADAYYE MGIHCWDVAG AGIIVTEAGG VLMDVTGGPF Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 95%.

IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IMPA1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Impa1
Gene Accession No. P29218
Gene Alias 2610002K09Rik; 2900059K10Rik; AI325909; D-galactose 1-phosphate phosphatase; IMP; IMP 1; IMPA; IMPA1; Impa1-L; IMPase 1; inositol (myo)-1(or 4)-monophosphatase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1; testicular tissue protein Li 94
Gene Symbols Impa1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human IMPA1. Recombinant protein control fragment (Product #RP-93793).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3612
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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