Invitrogen™ IMPA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529008

Catalog No. PIPA529008

Description

Recommended positive controls: PC-3, SK-N-SH. Predicted reactivity: Mouse (86%), Rat (85%), Pig (85%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.

Specifications

• Antigen: IMPA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Impa1
• Gene Alias: 2610002K09Rik; 2900059K10Rik; AI325909; D-galactose 1-phosphate phosphatase; IMP; IMP 1; IMPA; IMPA1; Impa1-L; IMPase 1; inositol (myo)-1(or 4)-monophosphatase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1; testicular tissue protein Li 94
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3612
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P29218
• Gene Symbols: Impa1
• Immunogen: Full length human IMPA1 Recombinant protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov