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IMPACT Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501563150
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Catalog No. Quantity
50-156-3150 100 μL
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Catalog No. 50-156-3150 Supplier Bethyl Laboratories, Inc Supplier No. A302661A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.

Specifications

Antigen IMPACT
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene IMPACT
Gene Accession No. Q9P2X3
Gene Alias Impact homolog, Impact homolog (mouse), imprinted and ancient gene protein homolog, RWD domain containing 5, RWDD5
Gene Symbols IMPACT
Host Species Rabbit
Immunogen Between 270 and 320
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55364
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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