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MilliporeSigma™ IMPACT, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABN1444MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABN1444MI 100 μL Unconjugated
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Catalog No. ABN1444MI Supplier MilliporeSigma™ Supplier No. ABN1444

Description

Rabbit Polyclonal Antibody

Protein IMPACT (UniProt Q9P2X3; also known as Imprinted and ancient gene protein homolog) is encoded by the IMPACT gene (Gene ID 55364) in human. IMPACT is a cytoplasmic protein preferentially expressed in neurons. IMPACT is highly abundant in the hypothalamus and in scattered neurons in other areas, such as the hippocampal interneurons. IMPACT and its yeast ortholog Yih1 contain an RWD domain (a.a. 14-116 of human and mouse IMPACT) that interacts with GCN1 and competes against GCN2 for GCN1 binding. IMPACT and Yih1 overexpression in mouse embryonic fibroblasts (MEFs) and yeasts inhibits GCN2 activation induction. IMPACT is a developmentally regulated protein that promotes neuritogenesis, while GCN2 strongly inhibits spontaneous neurite outgrowth. Increased abundance of IMPACT in differentiated neuronal cells enhances translation initiation by preventing GCN2 signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IMPACT
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene IMPACT
Gene Accession No. Q9P2X3
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to the C-terminal sequence of human IMPACT.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_060909
Test Specificity This polyclonal antibody was raised against the C-terminal end sequence present in both spliced isoforms of human IMPACT reported by UniProt (Q9P2X3).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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