MilliporeSigma™ IMPACT, Rabbit, Unlabeled, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABN1444

Catalog No. ABN1444MI

Description

Protein IMPACT (UniProt Q9P2X3; also known as Imprinted and ancient gene protein homolog) is encoded by the IMPACT gene (Gene ID 55364) in human. IMPACT is a cytoplasmic protein preferentially expressed in neurons. IMPACT is highly abundant in the hypothalamus and in scattered neurons in other areas, such as the hippocampal interneurons. IMPACT and its yeast ortholog Yih1 contain an RWD domain (a.a. 14-116 of human and mouse IMPACT) that interacts with GCN1 and competes against GCN2 for GCN1 binding. IMPACT and Yih1 overexpression in mouse embryonic fibroblasts (MEFs) and yeasts inhibits GCN2 activation induction. IMPACT is a developmentally regulated protein that promotes neuritogenesis, while GCN2 strongly inhibits spontaneous neurite outgrowth. Increased abundance of IMPACT in differentiated neuronal cells enhances translation initiation by preventing GCN2 signaling.

Specifications

• Antigen: IMPACT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IMPACT
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: This polyclonal antibody was raised against the C-terminal end sequence present in both spliced isoforms of human IMPACT reported by UniProt (Q9P2X3).
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.

• Applications: Western Blot
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: Q9P2X3
• Immunogen: KLH-conjugated linear peptide corresponding to the C-terminal sequence of human IMPACT.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_060909
• Target Species: Human

For Research Use Only. Not for use in diagnostic procedures.