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Importin 11/IPO11 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31

Specifications

Antigen Importin 11/IPO11
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-156-8743
Encompass_Preferred
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Bethyl Laboratories, Inc
A304811AT
20 μL
Each of 1 for $151.31
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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
Specifications

Specifications

Importin 11/IPO11
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
RanBP11
Between 925 and 975
Primary
4° C
IPO11
Western Blot
Unconjugated
Rabbit
Human, Mouse
Q8K2V6, Q9UI26
51194, 76582
IgG
Antigen affinity chromatography
Antibody
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