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Invitrogen™ Importin 11 Polyclonal Antibody
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Catalog No. PIPA564308
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100 μL
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PIPA564308 100 μL
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Catalog No. PIPA564308 Supplier Invitrogen™ Supplier No. PA564308
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QLLGNMIEMW VDRMDNITQP ERRKLSALAL LSLLPSDNSV IQDKFCGIIN ISVEGLHDVM TEDPETGTYK DCMLMSHLEE PKVTEDEEPP TEQD Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 77%.

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Importin 11
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene IPO11
Gene Accession No. Q9UI26
Gene Alias 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; Imp11; importin 11; importin-11; IPO11; Ran binding protein 11; ran-binding protein 11; Ranbp11
Gene Symbols IPO11
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Importin 11. Recombinant protein control fragment (Product #RP-104137).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51194
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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