Invitrogen™ Importin 11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141600

Catalog No. 01-675-217

Description

Suggested positive control: HeLa lysate, antigen standard for IPO11 (transient overexpression lysate).

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.

Specifications

• Antigen: Importin 11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO11
• Gene Alias: 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; Imp11; importin 11; importin-11; IPO11; Ran binding protein 11; ran-binding protein 11; Ranbp11
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 310056, 478073, 51194, 538236, 76582
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Accession No.: Q8K2V6, Q9UI26
• Gene Symbols: IPO11
• Immunogen: Synthetic peptide corresponding to residues 1-50 of humanImportin-11.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Bovine
• Product Type: Antibody
• Isotype: IgG