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Invitrogen™ Importin 11 Polyclonal Antibody
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Catalog No. 01675217
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100 μg
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Catalog No. Quantity
01-675-217 100 μg
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Catalog No. 01-675-217 Supplier Invitrogen™ Supplier No. PA141600
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Description

Rabbit Polyclonal Antibody

Suggested positive control: HeLa lysate, antigen standard for IPO11 (transient overexpression lysate).

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Importin 11
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene IPO11
Gene Accession No. Q8K2V6, Q9UI26
Gene Alias 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; Imp11; importin 11; importin-11; IPO11; Ran binding protein 11; ran-binding protein 11; Ranbp11
Gene Symbols IPO11
Host Species Rabbit
Immunogen A portion of amino acids 1-50 of human Importin-11.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 310056, 478073, 51194, 538236, 76582
Target Species Human, Mouse, Rat, Canine, Monkey, Bovine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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