Importin 4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA550433

Catalog No. PA550433

Description

The antibody detects endogenous levels of total IPO4 protein.

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Specifications

• Antigen: Importin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ipo4
• Gene Alias: 8430408O15Rik; AA409693; Imp4; Imp4a; IMP4B; importin 4; importin 4a; importin-4; Importin-4a; importin-4b; IPO4; Ran-binding protein 4; ranBP4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79711
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q8TEX9
• Gene Symbols: Ipo4
• Immunogen: Fusion protein corresponding to residues near the C terminal of human importin 4
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG