Importin 7 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A302726A

Catalog No. 50-156-3316

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Importin-7 (IOP7) belongs to the Importin beta family and contains an importin N-terminal domain. It functions in nuclear protein import in association with importin-beta subunit KPNB1. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 and thenuclear import of H2A, H2B, H3 and H4 histones in vitro.Studies suggest itacts as a nuclear import receptor for the Glucocorticoid receptors. It also acts as a receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.Reports indicatethat in HIV-1 infection,IOP7 binds and mediates the nuclear import of HIV-1 Rev.

Specifications

• Antigen: Importin 7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO7
• Gene Alias: FLJ14581, Imp7, MGC138673, RANBP7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10527
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/ml
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: O95373
• Gene Symbols: IPO7
• Immunogen: Between 50 and 100
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG