Importin 7 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-3319	100 μL

Catalog No. 50-156-3319 Supplier Bethyl Laboratories, Inc Supplier No. A302727A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Importin-7 (IOP7) belongs to the Importin beta family and contains an importin N-terminal domain. It functions in nuclear protein import in association with importin-beta subunit KPNB1. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 and thenuclear import of H2A, H2B, H3 and H4 histones in vitro.Studies suggest itacts as a nuclear import receptor for the Glucocorticoid receptors. It also acts as a receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.Reports indicatethat in HIV-1 infection,IOP7 binds and mediates the nuclear import of HIV-1 Rev.

Specifications

• Antigen: Importin 7
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/ml
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: IPO7
• Gene Accession No.: O95373, Q9EPL8
• Gene Alias: FLJ14581, Imp7, MGC138673, RANBP7
• Gene Symbols: IPO7
• Host Species: Rabbit
• Immunogen: Between 200 and 250
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10527, 233726
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG