Invitrogen™ Importin 8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550687

Catalog No. PA550687

Description

The antibody detects endogenous levels of total IPO8 protein.

Importin 8 is a 1037 amino acidnuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.

Specifications

• Antigen: Importin 8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO8
• Gene Alias: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; FLJ26580; imp8; importin 8; importin-8; IPO8; MRP7; Om1; OM-1; oocyte maturation 1; RAN binding protein 8; ran-binding protein 8; RANBP8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10526
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 2.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O15397
• Gene Symbols: IPO8
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human importin 8.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG