Invitrogen™ Importin 8 Polyclonal Antibody

Catalog No.	Quantity
PA550687	100 μL

Catalog No. PA550687 Supplier Invitrogen™ Supplier No. PA550687

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total IPO8 protein.

Importin 8 is a 1037 amino acidnuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.

Specifications

• Antigen: Importin 8
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 2.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: IPO8
• Gene Accession No.: O15397
• Gene Alias: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; FLJ26580; imp8; importin 8; importin-8; IPO8; MRP7; Om1; OM-1; oocyte maturation 1; RAN binding protein 8; ran-binding protein 8; RANBP8
• Gene Symbols: IPO8
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human importin 8.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10526
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG