Invitrogen™ Importin 8 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142011

Catalog No. PIPA5142011

Description

Additional Information: This antibody is expected to recognise isoform 1 (NP_006381.2) and isoform 2 (NP_001177924.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000. Preliminary analysis showed no signal in Western Blot.

Importin 8 is a 1037 amino acidnuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.

Specifications

• Antigen: Importin 8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO8
• Gene Alias: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; FLJ26580; imp8; importin 8; importin-8; IPO8; MRP7; Om1; OM-1; oocyte maturation 1; RAN binding protein 8; ran-binding protein 8; RANBP8
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 10526
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O15397
• Gene Symbols: IPO8
• Immunogen: Peptide with sequence C-SAFNFGTVPSNN.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG