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Invitrogen™ Importin 9 Polyclonal Antibody
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Catalog No. PIPA5102881
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PIPA5102881 100 μL
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Catalog No. PIPA5102881 Supplier Invitrogen™ Supplier No. PA5102881
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IPO9.

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Importin 9
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IPO9
Gene Accession No. Q96P70
Gene Alias 0710008K06Rik; AI845704; C78347; DKFZp761M1547; FLJ10402; HSPC273; Imp9; imp9a; imp9b; importin 9; importin-9; importin-9a; importin-9b; Ipo9; KIAA1192; mKIAA1192; Ran binding protein 9; ran-binding protein 9; RANBP9; RP11-90L20.4
Gene Symbols IPO9
Host Species Rabbit
Immunogen A synthesized peptide derived from human IPO9(Accession Q96P70), corresponding to amino acid residues G967-Q1017.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55705
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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