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Invitrogen™ Importin 9 Polyclonal Antibody
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Catalog No. 01675524
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100 μg
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Catalog No. Quantity
01-675-524 100 μg
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Catalog No. 01-675-524 Supplier Invitrogen™ Supplier No. PA141395
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, chicken, and opossum based on sequence homology. Suggested positive control: Hela whole cell extract, HeLa cell lysate. The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a, _b, _c), mouse (isoforms 1 and 2), 88% homologous in chicken, 83% homologous in opossum, and 78% in bovine.

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Importin 9
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene IPO9
Gene Accession No. Q91YE6, Q96P70
Gene Alias 0710008K06Rik; AI845704; C78347; DKFZp761M1547; FLJ10402; HSPC273; Imp9; imp9a; imp9b; importin 9; importin-9; importin-9a; importin-9b; Ipo9; KIAA1192; mKIAA1192; Ran binding protein 9; ran-binding protein 9; RANBP9; RP11-90L20.4
Gene Symbols IPO9
Host Species Rabbit
Immunogen A portion of amino acids 850-950 of human Importin-9.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 226432, 304817, 480004, 55705, 707210
Target Species Human, Mouse, Rat, Canine, Monkey, Rhesus Macaque
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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