Invitrogen™ Importin 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141395

Catalog No. 01-675-524

Description

This antibody is predicted to react with bovine, chicken, and opossum based on sequence homology. Suggested positive control: Hela whole cell extract, HeLa cell lysate.

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.

Specifications

• Antigen: Importin 9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO9
• Gene Alias: 0710008K06Rik; AI845704; C78347; DKFZp761M1547; FLJ10402; HSPC273; Imp9; imp9a; imp9b; importin 9; importin-9; importin-9a; importin-9b; Ipo9; KIAA1192; mKIAA1192; Ran binding protein 9; ran-binding protein 9; RANBP9; RP11-90L20.4
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 226432, 304817, 480004, 55705, 707210
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Accession No.: Q91YE6, Q96P70
• Gene Symbols: IPO9
• Immunogen: Synthetic peptide corresponding to residues 850-950 of humanImportin-9.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Rhesus Macaque
• Product Type: Antibody
• Isotype: IgG