Invitrogen™ Importin beta-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597132

Catalog No. PIPA597132

Description

Positive Samples: Raji, U-87MG, MCF7, HeLa, HepG2, mouse testis, mouse thymus, LO2, Mouse testis, Mouse lung, Mouse brain, Rat liver; Cellular Location: Cytoplasm, Nucleus envelope Immunogen sequence: AAEQGRPPEH TSKFYAKGAL QYLVPILTQT LTKQDENDDD DDWNPCKAAG VCLMLLATCC EDDIVPHVLP FIKEHIKNPD WRYRDAAVMA FGCILEGPEP S.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Specifications

• Antigen: Importin beta-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KPNB1
• Gene Alias: AA409963; HGNC:6400; IMB1; Impnb; importin 1; importin 90; importin beta; importin beta-1 subunit; importin subunit beta-1; Importin-90; IPO1; IPOB; KapB1; karyopherin (importin) beta 1; karyopherin beta 1; karyopherin subunit beta 1; karyopherin subunit beta-1; karyopherin,beta 1; Kpnb1; MGC2155; MGC2156; MGC2157; NTF97; Nuclear factor p97; pore targeting complex 97 kDa subunit; PTAC97; SCG
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16211, 24917, 3837
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.09 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P52296, P70168, Q14974
• Gene Symbols: KPNB1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human KPNB1 (NP_0022562).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG